Anti-Alzeheimer Activity of Novel 1,3,4-thiadiazole derivatives

The reaction of the new enaminone 2 with α-ketohydrazonoyl chlorides 3 afforded 5-(pyrazol-4-yl)-carbonyl-2-benzoylimino-1,3,4-thiadiazoles 5. Treatment of 5a with hydrazine hydrate led to formation of pyrazolo[3,4-d] pyridazine derivatives 8. The reaction of enaminone 2 with 6-amino-2-thioxopyrimidin-4-one 9 in acetic acid under reflux produced 2- thioxopyridopyrimidinone derivative 10.